| Player | Pos | Team |
|---|---|---|
| Grayson O'Bara | WR | North Texas Mean Green |
| Antonio O'Berry | LB | Kentucky Wildcats |
| Liam O'Brien | QB | Cincinnati Bearcats |
| Colin O'Carroll | OL | Tulane Green Wave |
| Ryan O'Connell | LB | USC Trojans |
| Ethan O'Connor | DB | Miami Hurricanes |
| Kevin O'Connor | DE | Duke Blue Devils |
| Michael O'Connor | LS | Rutgers Scarlet Knights |
| Sean O'Haire | PK | Maryland Terrapins |
| Tomas O'Halloran | P | East Carolina Pirates |
| Thomas O'Hara | P | Kentucky Wildcats |
| Tomas O'Meara | RB | Michigan Wolverines |
| Carmelo O'Neal | DB | Alabama Crimson Tide |
| J.J. O'Neal | S | Missouri State Bears |
| Danny O'Neil | QB | Wisconsin Badgers |
| Grady O'Neill | WR | Sam Houston Bearkats |
| Miles O'Neill | QB | North Carolina Tar Heels |
| Caden O'Rourke | DL | Northwestern Wildcats |
| Jayden O'Rourke | TE | Nevada Wolf Pack |
| Walker O'Steen | LB | Jacksonville State Gamecocks |
| Garrett Oakley | TE | Kansas State Wildcats |
| Iman Oates | DT | Oklahoma State Cowboys |
| Jehiem Oatis | DT | Ole Miss Rebels |
| Kevin Oatis | DT | Kansas Jayhawks |
| Yousef Obeid | PK | Missouri State Bears |
| Chiddi Obiazor | DL | Indiana Hoosiers |
| Ify Obidegwu | DB | Oregon Ducks |
| Gael Ochoa | QB | Rice Owls |
| Jordan Ochoa | EDGE | Nebraska Cornhuskers |
| Jacob Oden | S | Michigan Wolverines |
| Ezra Odinjor | DE | Toledo Rockets |
| Jabari Odoemenem | LB | Oregon State Beavers |
| AJ Odom | LB | Bowling Green Falcons |
| Amari Odom | QB | Syracuse Orange |
| Caleb Odom | TE | Ole Miss Rebels |
| Jojo Odom | DL | Louisiana Tech Bulldogs |
| Kenny Odom | WR | South Florida Bulls |
| Marlin Odom | CB | Troy Trojans |
| Na'eem Offord | DB | Oregon Ducks |
| Cheta Ofili | LB | TCU Horned Frogs |
| Jesse Ofurie | DB | Rutgers Scarlet Knights |
| Nissi Ogbebor | DL | Syracuse Orange |
| Nnamdi Ogboko | DL | Georgia Bulldogs |
| Ahran Ogbor | S | Rice Owls |
| Matt Ogunniyi | TE | Massachusetts Minutemen |
| Emmanuel Oguns | DL | Louisiana Tech Bulldogs |
| Jadyn Oh | PK | Oregon State Beavers |
| Theo Melin Ohrstrom | TE | SMU Mustangs |
| Che Ojarikre | CB | Duke Blue Devils |
| Caleb Ojeda | PK | Oregon State Beavers |
| Odera Okaka | LB | California Golden Bears |
| David Oke | DL | Arkansas Razorbacks |
| Chukwunedu Okeke | DL | James Madison Dukes |
| Obinna Okeke | DE | New Mexico State Aggies |
| Daniel Okonkwo | S | Georgia Bulldogs |
| George Okorie | DE | Ball State Cardinals |
| Justin Okoronkwo | LB | South Carolina Gamecocks |
| Chuma Okoye | DE | Georgia Tech Yellow Jackets |
| Danny Okoye | DL | Oklahoma Sooners |
| Emmanuel Okoye | LB | California Golden Bears |
| Eduwa Okundaye | DE | Washington State Cougars |
| Samuel Okunlola | DL | Virginia Tech Hokies |
| Michael-Anthony Okwura | DL | California Golden Bears |
| Caleb Olabode | LB | Missouri State Bears |
| Israel Oladipupo | DL | Boston College Eagles |
| Emmanuel Olagbaju | DL | Iowa Hawkeyes |
| David Olano | PK | Texas A&M Aggies |
| Tobi Olawole | WR | Army Black Knights |
| Jayden Olden | LB | East Carolina Pirates |
| Caleb Oliver | EDGE | Buffalo Bulls |
| Jason Oliver | CB | San Diego State Aztecs |
| John Wayne Oliver | OL | Ole Miss Rebels |
| Jed Olotu-Judah | LB | Old Dominion Monarchs |
| Eric Olsen | TE | Oregon State Beavers |
| Jack Olsen | PK | Miami Hurricanes |
| Ty Olsen | WR | Utah State Aggies |
| Quinn Olson | S | Arizona Wildcats |
| Donovan Olugbode | WR | Missouri Tigers |
| Sean Olvera-Harle | PK | Hawai'i Rainbow Warriors |
| Jaimion Olverson | DE | Bowling Green Falcons |
| Troy Omeire | WR | New Mexico Lobos |
| Paul Omodia | DB | Colorado Buffaloes |
| Mo Omonode | DL | Minnesota Golden Gophers |
| David Omopariola | LB | Syracuse Orange |
| Sammy Omosigho | LB | UCLA Bruins |
| Fawzy Omotoso | DE | Northern Illinois Huskies |
| Irabonoise Oniha | CB | Navy Midshipmen |
| Jordan Onovughe | WR | Stanford Cardinal |
| Kainoa Ontai | DB | Hawai'i Rainbow Warriors |
| Bo Onu | S | Baylor Bears |
| David Onuoha | DL | North Texas Mean Green |
| Sampson Onuoha | DE | Duke Blue Devils |
| Jason Onye | DL | Notre Dame Fighting Irish |
| Jayden Oquendo | DL | Air Force Falcons |
| Curly Ordonez | LB | Temple Owls |
| Alex Orji | QB | UNLV Rebels |
| Smith Orogbo | EDGE | Texas Longhorns |
| Zach Ortwerth | TE | Iowa Hawkeyes |
| Lucas Osada | PK | Illinois Fighting Illini |
| LaDavion Osborn | CB | Toledo Rockets |
| Hunter Osborne | DL | Arkansas Razorbacks |
| Kalieb Osborne | QB | UConn Huskies |
| Nick Osho | RB | North Texas Mean Green |
| Eze Osondu | LB | UTSA Roadrunners |
| Cade Osterman | WR | North Dakota State Bison |
| Addison Ostrenga | TE | Iowa Hawkeyes |
| Tobi Osunsanmi | DL | Indiana Hoosiers |
| Jamih Otis | LB | Hawai'i Rainbow Warriors |
| Jaxon Ott | LB | Purdue Boilermakers |
| Joe Otting | OL | Notre Dame Fighting Irish |
| André Otto | OL | Florida State Seminoles |
| Nico Ottomanelli | PK | Sam Houston Bearkats |
| Chidera Otutu | DL | Cincinnati Bearcats |
| Issa Ouattara | DL | Vanderbilt Commodores |
| Dominic Overby | WR | Iowa State Cyclones |
| Patrick Overmyer | TE | Houston Cougars |
| Taijh Overton | S | UL Monroe Warhawks |
| Bisi Owens | WR | Purdue Boilermakers |
| Chancellor Owens | DL | Texas State Bobcats |
| Coby Owens | LB | Georgia State Panthers |
| Daniel Owens | TE | Maryland Terrapins |
| John Owens | LS | Boston College Eagles |
| Trey Owens | QB | Arkansas State Red Wolves |
| Walter Owens | S | New Mexico State Aggies |
| Martin Owusu | DL | Fresno State Bulldogs |
| Nathaniel Owusu-Boateng | LB | Michigan Wolverines |
| MarShon Oxley | LB | South Florida Bulls |
| Ehimen Oyamendan | DB | Air Force Falcons |
| Emmanuel Oyebadejo | DL | Florida Gators |
| Paul Oyewale | LB | TCU Horned Frogs |
| Jack Oyola | DB | Northwestern Wildcats |
| Eli Ozick | PK | Iowa Hawkeyes |
| Kenny Ozowalu | DL | Oklahoma Sooners |