| Player | Pos | Team |
|---|---|---|
| Kanye Udoh | RB | Liberty Flames |
| Courage Ugo | DB | UAB Blazers |
| Richmond Ugochukwu | LB | Houston Cougars |
| Matayo Uiagalelei | LB | Oregon Ducks |
| Ta'ita'i Uiagalelei | DL | Washington Huskies |
| Brock Uihlein | LB | Miami (OH) RedHawks |
| Tama Uiliata | WR | Hawai'i Rainbow Warriors |
| Tommy Ulatowski | QB | App State Mountaineers |
| Jacob Ulrich | P | Oklahoma Sooners |
| Cade Uluave | LB | BYU Cougars |
| Princewill Umanmielen | DE | LSU Tigers |
| Benedict Umeh | DL | Stanford Cardinal |
| Obinna Umeh | DE | Duke Blue Devils |
| Desmond Umeozulu | LB | Alabama Crimson Tide |
| Zina Umeozulu | EDGE | Texas Longhorns |
| Tufanua Ionatana Umu-Cais | DL | Washington Huskies |
| Bryce Underwood | QB | Michigan Wolverines |
| Lukas Ungar | TE | Virginia Cavaliers |
| Camen Upshaw | S | South Alabama Jaguars |
| Daylyn Upshaw | WR | Miami Hurricanes |
| Will Upshaw | DL | Tulsa Golden Hurricane |
| Marcus Upton | DB | Boston College Eagles |
| Will Upton | WR | Auburn Tigers |
| Kennedy Urlacher | S | USC Trojans |
| Chase Usher | DB | Charlotte 49ers |
| Ethan Utley | DL | Tennessee Volunteers |
| Donte Utu | S | Stanford Cardinal |
| Poasa Utu | LB | Nevada Wolf Pack |
| Jeff Utzinger | LB | Indiana Hoosiers |
| Ilya Uvaydov | PK | New Mexico State Aggies |